Development of Intracellular Signal Transduction Modulators

Systems biological analyses of intracellular signal transduction

Neurotrophic Factors and Intracellular Signal Transduction Pathways

A clear limitation of treating diseases of the central nervous system arises from the loss of regenerative potential of the brain at a very early age. Improper development of neural circuits or injury of neurons appears to be permanently fixed in the adult, with seemingly little hope of restorative therapy. This is most clearly true of the spectrum of neurologic diseases, such as neurodegenerat...

Cytoplasmic RNA modulators of an inside-out signal-transduction cascade.

A vaccinia virus-based RNA expression system enabled high-level cytoplasmic expression of RNA aptamers directed against the intracellular domain of the beta2 integrin LFA-1, a transmembrane protein that mediates cell adhesion to intercellular adhesion molecule-1 (ICAM-1). In two different cell types, cytoplasmic expression of integrin-binding aptamers reduced inducible cell adhesion to ICAM-1. ...

Studies of New Signal Transduction Modulators in Acute Myeloid Leukemia

Eriksson, A. 2012. Studies of New Signal Transduction Modulators in Acute Myeloid Leukemia. Acta Universitatis Upsaliensis. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 823. 61 pp. Uppsala. ISBN 978-91-554-8495-8. Acute myeloid leukemia (AML) is a life-threatening malignant disorder with dismal prognosis. AML is characterized by frequent genetic changes ...

Neuronal Development and Signal Transduction

Neuronal differentiation is a complex neurobiological phenomenon that includes a series of events that are developmentally regulated. The first step in differentiation is a block of proliferation, leading from a round, cycling neuroblast to a flat quiescent neuron. This is followed by the process of extension of neurites, that represents the starting point for the morphological and functional p...